Levoleucovorin

CHEMBL1908841 Phase 4 معتمد Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

473.4 g/mol

LogP

-1.2

Phase

4

The L-isomer of leucovorin (folinic acid) used to rescue normal cells from methotrexate toxicity and enhance the activity of fluorouracil in colorectal cancer treatment. It is more biologically active than the racemic leucovorin mixture.

الوزن الجزيئي

473,4000 g/mol

LogP

-1,20

TPSA

216,00 Å²

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Rheumatoid Arthritis Schizophrenia Melanoma Oncology Psoriasis Lymphoma Breast Cancer Hepatitis C Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

SVG PNG

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SMILES

Nc1nc(=O)c2c([nH]1)NC[C@H](CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)N2C=O

InChI

InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1

Molecular Formula

C20H23N7O7

HBD / HBA

7 / 10

الروابط القابلة للدوران

9

الذرات الثقيلة

34

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

The L-isomer of leucovorin (folinic acid) used to rescue normal cells from methotrexate toxicity and enhance the activity of fluorouracil in colorectal cancer treatment. It is more biologically active than the racemic leucovorin mixture.

Yes, Levoleucovorin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1908841. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 135398559. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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البنية

بيانات سريعة

الصيغة الجزيئية: C20H23N7O7
المرادفات: 2

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إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.