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Lovastatin

CHEMBL503 Phase 4 معتمد Small molecule
Half-Life
2-3 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
404.5 g/mol
LogP
4.3
Phase
4

A naturally occurring statin originally derived from fungus, used to lower LDL cholesterol and reduce the risk of cardiovascular events, and studied for potential anticancer and neuroprotective effects. It inhibits HMG-CoA reductase, the key enzyme in cholesterol synthesis.

الوزن الجزيئي

404,5390 g/mol

LogP

4,30

TPSA

72,80 Ų

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Endometriosis Cardiovascular Disease Pain Management Non-Small Cell Lung Cancer Rheumatoid Arthritis Osteoporosis Asthma Chronic Obstructive Pulmonary Disease Alzheimer's Disease Epilepsy Migraine Schizophrenia Bipolar Disorder Melanoma Systemic Lupus Erythematosus Multiple Sclerosis Chronic Kidney Disease Stroke Hyperlipidemia Obesity Lymphoma Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer Chronic Pain Hepatitis C Heart Failure Atrial Fibrillation Prostate Cancer Colorectal Cancer Leukemia

تصنيفات الأدوية

C — C - Cardiovascular System

آلية العمل

First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.

Pharmacokinetics (PK)

Half-Life 2-3 hours

Pharmacodynamics (PD)

الآلية

First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21

                

                

                
                

                    
InChI

                    
InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C24H36O5

                    

                    
                    

                        
HBD / HBA

                        
1 / 5

                    

                    
                    

                        
الروابط القابلة للدوران

                        
7

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
29

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
A naturally occurring statin originally derived from fungus, used to lower LDL cholesterol and reduce the risk of cardiovascular events, and studied for potential anticancer and neuroprotective effects. It inhibits HMG-CoA reductase, the key enzyme in cholesterol synthesis.

                        

                    

                    

                    

                    
                    

                        
                        

                            
First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Lovastatin: Half-life: 2-3 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Lovastatin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Atorvastatin
                            Small molecule
                        
                        
                        
                            Amlodipine
                            Small molecule
                        
                        
                        
                            Lisinopril
                            Small molecule
                        
                        
                        
                            Metoprolol
                            Small molecule
                        
                        
                    

                

                

                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL503.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 53232.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.