Maralixibat

CHEMBL363392 Phase 4 معتمد Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

675.0 g/mol

LogP

7.1

Phase

4

An ileal bile acid transporter (IBAT) inhibitor used to treat cholestatic pruritus (severe itching) in children with progressive familial intrahepatic cholestasis (PFIC) by reducing the reabsorption of bile acids from the intestine. This helps lower bile acid levels in the blood and alleviate itching.

الوزن الجزيئي

675,0000 g/mol

LogP

7,10

TPSA

78,50 Å²

قاعدة ليبينسكي للخمسة

راسب

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

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SMILES

CCCCC1(CCCC)CS(=O)(=O)c2ccc(N(C)C)cc2[C@@H](c2ccc(OCc3ccc(C[N+]45CCN(CC4)CC5)cc3)cc2)[C@H]1O

InChI

InChI=1S/C40H56N3O4S/c1-5-7-19-40(20-8-6-2)30-48(45,46)37-18-15-34(41(3)4)27-36(37)38(39(40)44)33-13-16-35(17-14-33)47-29-32-11-9-31(10-12-32)28-43-24-21-42(22-25-43)23-26-43/h9-18,27,38-39,44H,5-8,19-26,28-30H2,1-4H3/q+1/t38-,39-/m1/s1

Molecular Formula

C40H56N3O4S+

HBD / HBA

1 / 6

الروابط القابلة للدوران

13

الذرات الثقيلة

48

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

An ileal bile acid transporter (IBAT) inhibitor used to treat cholestatic pruritus (severe itching) in children with progressive familial intrahepatic cholestasis (PFIC) by reducing the reabsorption of bile acids from the intestine. This helps lower bile acid levels in the blood and alleviate itching.

Yes, Maralixibat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL363392. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 9831643. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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البنية

بيانات سريعة

الصيغة الجزيئية: C40H56N3O4S+
المرادفات: 1

روابط خارجية

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إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.