Pacritinib

CHEMBL2035187 Phase 4 معتمد Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

472.6 g/mol

LogP

3.8

Phase

4

A kinase inhibitor used to treat myelofibrosis, a bone marrow cancer that disrupts normal blood cell production, particularly in patients with low platelet counts who cannot tolerate other treatments. It blocks signaling pathways that drive abnormal cell growth in the bone marrow.

الوزن الجزيئي

472,6000 g/mol

LogP

3,80

TPSA

68,70 Å²

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Non-Small Cell Lung Cancer Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

SVG PNG

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SMILES

C1=N/C2=N/c3ccc(OCCN4CCCC4)c(c3)COC/C=C/COCc3cccc(c3)C(=C1)N2

InChI

InChI=1S/C28H32N4O3/c1-2-13-32(12-1)14-17-35-27-9-8-25-19-24(27)21-34-16-4-3-15-33-20-22-6-5-7-23(18-22)26-10-11-29-28(30-25)31-26/h3-11,18-19H,1-2,12-17,20-21H2,(H,29,30,31)/b4-3+

Molecular Formula

C28H32N4O3

HBD / HBA

1 / 7

الروابط القابلة للدوران

4

الذرات الثقيلة

35

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

A kinase inhibitor used to treat myelofibrosis, a bone marrow cancer that disrupts normal blood cell production, particularly in patients with low platelet counts who cannot tolerate other treatments. It blocks signaling pathways that drive abnormal cell growth in the bone marrow.

Yes, Pacritinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2035187. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 46216796. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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البنية

بيانات سريعة

الصيغة الجزيئية: C28H32N4O3
المرادفات: 1

روابط خارجية

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إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.