Pafolacianine

CHEMBL4297412 Phase 4 معتمد Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

1326.5 g/mol

LogP

4.0

Phase

4

A fluorescent dye activated by near-infrared light that targets folate receptors overexpressed on ovarian cancer cells, used during surgery to help surgeons identify and remove cancer tissue more precisely. It is injected before surgery and illuminated with a special camera system in the operating room.

الوزن الجزيئي

1326,5000 g/mol

LogP

4,00

TPSA

441,00 Å²

قاعدة ليبينسكي للخمسة

راسب

المجالات العلاجية

Ovarian Cancer Bladder Cancer Non-Small Cell Lung Cancer Prostate Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

SVG PNG

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SMILES

CC1(C)C(/C=C/C2=C(Oc3ccc(C[C@H](NC(=O)c4ccc(NCc5cnc6nc(N)[nH]c(=O)c6n5)cc4)C(=O)[O-])cc3)/C(=C/C=C3\N(CCCCS(=O)(=O)[O-])c4ccc(S(=O)(=O)[O-])cc4C3(C)C)CCC2)=[N+](CCCCS(=O)(=O)[O-])c2ccc(S(=O)(=O)[O-])cc21.[H+].[H+].[H+].[H+]

InChI

InChI=1S/C61H67N9O17S4/c1-60(2)46-33-44(90(81,82)83)22-24-49(46)69(28-5-7-30-88(75,76)77)51(60)26-16-38-10-9-11-39(17-27-52-61(3,4)47-34-45(91(84,85)86)23-25-50(47)70(52)29-6-8-31-89(78,79)80)54(38)87-43-20-12-37(13-21-43)32-48(58(73)74)66-56(71)40-14-18-41(19-15-40)63-35-42-36-64-55-53(65-42)57(72)68-59(62)67-55/h12-27,33-34,36,48H,5-11,28-32,35H2,1-4H3,(H9-,62,63,64,66,67,68,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86)/t48-/m0/s1

Molecular Formula

C61H67N9O17S4

HBD / HBA

8 / 22

الروابط القابلة للدوران

24

الذرات الثقيلة

91

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

A fluorescent dye activated by near-infrared light that targets folate receptors overexpressed on ovarian cancer cells, used during surgery to help surgeons identify and remove cancer tissue more precisely. It is injected before surgery and illuminated with a special camera system in the operating room.

Yes, Pafolacianine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4297412. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 135565623. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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البنية

بيانات سريعة

الصيغة الجزيئية: C61H67N9O17S4
المرادفات: 1

روابط خارجية

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إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.