Piflufolastat F18

CHEMBL4297334 Phase 4 معتمد Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

441.4 g/mol

LogP

-0.1

Phase

4

Piflufolastat F18 is a fluorine-18 radiolabeled small molecule PSMA-targeted PET imaging agent used for the detection and localization of PSMA-positive lesions in prostate, bladder, and breast cancer staging and restaging. It functions by selectively binding to prostate-specific membrane antigen expressed on tumor cells and tumor neovasculature, enabling precise lesion detection by PET imaging.

الوزن الجزيئي

441,4000 g/mol

LogP

-0,10

TPSA

195,00 Å²

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Breast Cancer Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

SVG PNG

Cite this structure

Embed this structure

SMILES

O=C(O)CC[C@H](NC(=O)N[C@@H](CCCCNC(=O)c1ccc([18F])nc1)C(=O)O)C(=O)O

InChI

InChI=1S/C18H23FN4O8/c19-13-6-4-10(9-21-13)15(26)20-8-2-1-3-11(16(27)28)22-18(31)23-12(17(29)30)5-7-14(24)25/h4,6,9,11-12H,1-3,5,7-8H2,(H,20,26)(H,24,25)(H,27,28)(H,29,30)(H2,22,23,31)/t11-,12-/m0/s1/i19-1

Molecular Formula

C18H23FN4O8

HBD / HBA

6 / 10

الروابط القابلة للدوران

13

الذرات الثقيلة

31

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

Piflufolastat F18 is a fluorine-18 radiolabeled small molecule PSMA-targeted PET imaging agent used for the detection and localization of PSMA-positive lesions in prostate, bladder, and breast cancer staging and restaging. It functions by selectively binding to prostate-specific membrane antigen expressed on tumor cells and tumor neovasculature, enabling precise lesion detection by PET imaging.

Yes, Piflufolastat F18 is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4297334. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 52950901. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

PillFYI

هل تبحث عن معلومات ملائمة للمرضى؟

Piflufolastat F18 على PillFYI

البنية

بيانات سريعة

الصيغة الجزيئية: C18H23FN4O8

روابط خارجية

Cite

BibTeX, APA, MLA, Chicago, IEEE, Harvard

إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.