Proxibarbal
Proxibarbal is a barbiturate-class anticonvulsant and sedative-hypnotic that enhances GABA-A receptor-mediated inhibitory neurotransmission by prolonging chloride channel opening time and at higher concentrations directly activating the chloride channel. It was used for the management of epilepsy and as a sedative, though like all barbiturates it carries significant risk of dependence and respiratory depression.
الوزن الجزيئي
226,2300 g/mol
LogP
0,20
TPSA
95,50 Ų
قاعدة ليبينسكي للخمسة
ناجح
Pharmacokinetics (PK)
Pharmacodynamics (PD)
البنية ثنائية الأبعاد
Cite this structure
Embed this structure
SMILES
C=CCC1(CC(C)O)C(=O)NC(=O)NC1=O
InChI
InChI=1S/C10H14N2O4/c1-3-4-10(5-6(2)13)7(14)11-9(16)12-8(10)15/h3,6,13H,1,4-5H2,2H3,(H2,11,12,14,15,16)
Molecular Formula
C10H14N2O4
HBD / HBA
3 / 4
الروابط القابلة للدوران
4
الذرات الثقيلة
16
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
الأسئلة الشائعة
Proxibarbal is a barbiturate-class anticonvulsant and sedative-hypnotic that enhances GABA-A receptor-mediated inhibitory neurotransmission by prolonging chloride channel opening time and at higher concentrations directly activating the chloride channel. It was used for the management of epilepsy and as a sedative, though like all barbiturates it carries significant risk of dependence and respiratory depression.
Yes, Proxibarbal is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105233. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 17336. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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