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Pyrithione Zinc

CHEMBL1200471 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
317.7 g/mol
LogP
—
Phase
4

Pyrithione zinc is a coordination complex of zinc and pyrithione with broad-spectrum antifungal and antibacterial activity that acts by disrupting membrane proton gradients and inhibiting key metabolic enzymes in Malassezia and other microorganisms. It is widely used in over-the-counter shampoos for dandruff and seborrheic dermatitis treatment, and in topical preparations for various dermatological conditions.

الوزن الجزيئي

317,7000 g/mol

TPSA

52,90 Ų

آلية العمل

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
[O-][n+]1ccccc1[S-].[O-][n+]1ccccc1[S-].[Zn+2]

                

                

                
                

                    
InChI

                    
InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H8N2O2S2Zn

                    

                    
                    

                        
HBD / HBA

                        
- / 4

                    

                    
                    

                        
الروابط القابلة للدوران

                        
2

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
17

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
Pyrithione zinc is a coordination complex of zinc and pyrithione with broad-spectrum antifungal and antibacterial activity that acts by disrupting membrane proton gradients and inhibiting key metabolic enzymes in Malassezia and other microorganisms. It is widely used in over-the-counter shampoos for dandruff and seborrheic dermatitis treatment, and in topical preparations for various dermatological conditions.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Pyrithione Zinc is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200471.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 26041.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.