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Remoxipride

CHEMBL22242 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
371.3 g/mol
LogP
2.1
Phase
4

Remoxipride is a selective dopamine D2 and D3 receptor antagonist antipsychotic of the benzamide class with a pharmacological profile similar to raclopride, demonstrating antipsychotic efficacy with a lower propensity for extrapyramidal side effects than typical antipsychotics. It was withdrawn from the market due to an association with aplastic anemia, a rare but potentially fatal bone marrow failure condition.

الوزن الجزيئي

371,2700 g/mol

LogP

2,10

TPSA

50,80 Ų

قاعدة ليبينسكي للخمسة

ناجح

آلية العمل

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC

                

                

                
                

                    
InChI

                    
InChI=1S/C16H23BrN2O3/c1-4-19-9-5-6-11(19)10-18-16(20)14-13(21-2)8-7-12(17)15(14)22-3/h7-8,11H,4-6,9-10H2,1-3H3,(H,18,20)/t11-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H23BrN2O3

                    

                    
                    

                        
HBD / HBA

                        
1 / 4

                    

                    
                    

                        
الروابط القابلة للدوران

                        
6

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
Remoxipride is a selective dopamine D2 and D3 receptor antagonist antipsychotic of the benzamide class with a pharmacological profile similar to raclopride, demonstrating antipsychotic efficacy with a lower propensity for extrapyramidal side effects than typical antipsychotics. It was withdrawn from the market due to an association with aplastic anemia, a rare but potentially fatal bone marrow failure condition.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Remoxipride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL22242.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 54477.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.