Repotrectinib

CHEMBL4298138 Phase 4 معتمد Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

355.4 g/mol

LogP

2.1

Phase

4

A next-generation ROS1 and TRK inhibitor used to treat non-small cell lung cancer with ROS1 gene fusions, including cancers that have developed resistance to earlier targeted therapies. It is designed to overcome common resistance mutations that limit the effectiveness of first-generation inhibitors.

الوزن الجزيئي

355,4000 g/mol

LogP

2,10

TPSA

80,60 Å²

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

SVG PNG

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SMILES

C[C@H]1CNC(=O)c2cnn3ccc(nc23)N[C@H](C)c2cc(F)ccc2O1

InChI

InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/m0/s1

Molecular Formula

C18H18FN5O2

HBD / HBA

2 / 6

الروابط القابلة للدوران

0

الذرات الثقيلة

26

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

A next-generation ROS1 and TRK inhibitor used to treat non-small cell lung cancer with ROS1 gene fusions, including cancers that have developed resistance to earlier targeted therapies. It is designed to overcome common resistance mutations that limit the effectiveness of first-generation inhibitors.

Yes, Repotrectinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4298138. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 135565923. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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البنية

بيانات سريعة

الصيغة الجزيئية: C18H18FN5O2
المرادفات: 1

روابط خارجية

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إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.