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Sertaconazole

CHEMBL1201196 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
437.8 g/mol
LogP
6.3
Phase
4

Sertaconazole is a benzothiophene-substituted imidazole antifungal agent used topically for the treatment of tinea pedis (athlete's foot) and atopic dermatitis complicated by fungal infection. It exerts dual antifungal activity by inhibiting fungal cytochrome P450-mediated lanosterol demethylation (disrupting ergosterol synthesis) and by direct membrane disruption through its benzothiophene moiety. The dual mechanism provides broad-spectrum activity against dermatophytes and Candida species.

الوزن الجزيئي

437,8000 g/mol

LogP

6,30

TPSA

55,30 Ų

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Atopic Dermatitis

آلية العمل

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C20H15Cl3N2OS/c21-14-4-5-16(18(23)8-14)19(9-25-7-6-24-12-25)26-10-13-11-27-20-15(13)2-1-3-17(20)22/h1-8,11-12,19H,9-10H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C20H15Cl3N2OS

                    

                    
                    

                        
HBD / HBA

                        
- / 3

                    

                    
                    

                        
الروابط القابلة للدوران

                        
6

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
27

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
Sertaconazole is a benzothiophene-substituted imidazole antifungal agent used topically for the treatment of tinea pedis (athlete's foot) and atopic dermatitis complicated by fungal infection. It exerts dual antifungal activity by inhibiting fungal cytochrome P450-mediated lanosterol demethylation (disrupting ergosterol synthesis) and by direct membrane disruption through its benzothiophene moiety. The dual mechanism provides broad-spectrum activity against dermatophytes and Candida species.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Sertaconazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201196.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 65863.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.