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Sugemalimab

CHEMBL4594535 Phase 4 معتمد Antibody
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
— g/mol
LogP
—
Phase
4

Sugemalimab is a fully human monoclonal IgG4 antibody targeting programmed death ligand 1 (PD-L1), used as an immune checkpoint inhibitor for the treatment of non-small cell lung cancer and classical Hodgkin lymphoma. By blocking the PD-1/PD-L1 inhibitory axis, it restores T-cell antitumor immune responses that are suppressed by PD-L1 expression on tumor cells and the tumor microenvironment. It has demonstrated improved progression-free and overall survival in combination with chemotherapy.

المجالات العلاجية

Non-Small Cell Lung Cancer Lymphoma

آلية العمل

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

HBD / HBA

- / -

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

Sugemalimab is a fully human monoclonal IgG4 antibody targeting programmed death ligand 1 (PD-L1), used as an immune checkpoint inhibitor for the treatment of non-small cell lung cancer and classical Hodgkin lymphoma. By blocking the PD-1/PD-L1 inhibitory axis, it restores T-cell antitumor immune responses that are suppressed by PD-L1 expression on tumor cells and the tumor microenvironment. It has demonstrated improved progression-free and overall survival in combination with chemotherapy.

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

Yes, Sugemalimab is an approved drug. It has reached clinical phase 4. It is classified as a Antibody.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

  • ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4594535. Open-access bioactivity database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.

إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.