💊 الأدوية من أ إلى ي 🧬 الأهداف 🛠 الأدوات 📚 الأدلة
جميع الأدوية تصنيفات الأدوية المجالات العلاجية الآثار الجانبية
الأدلة المسرد الجدول الزمني
المقارنات مسارات الأدوية عائلات الأدوية
🇺🇸 English 🇰🇷 한국어 🇯🇵 日本語 🇨🇳 中文简体 🇪🇸 Español 🇧🇷 Português 🇮🇳 हिन्दी 🇸🇦 العربية 🇫🇷 Français 🇷🇺 Русский 🇩🇪 Deutsch 🇹🇷 Türkçe 🇻🇳 Tiếng Việt 🇮🇩 Bahasa Indonesia 🇹🇭 ไทย

Tarlatamab

CHEMBL5095292 Phase 4 معتمد Antibody
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
— g/mol
LogP
—
Phase
4

Tarlatamab is a bispecific T-cell engager (BiTE) antibody that bridges delta-like ligand 3 (DLL3)-expressing tumor cells with CD3-positive T cells, inducing T-cell-mediated cytotoxicity. It is approved for the treatment of extensive-stage small cell lung cancer after prior platinum-based chemotherapy, and is under investigation for bladder cancer and melanoma. DLL3 is highly expressed in small cell lung cancer and other neuroendocrine tumors, making it a highly selective therapeutic target.

المجالات العلاجية

Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Melanoma Prostate Cancer

آلية العمل

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

HBD / HBA

- / -

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

Tarlatamab is a bispecific T-cell engager (BiTE) antibody that bridges delta-like ligand 3 (DLL3)-expressing tumor cells with CD3-positive T cells, inducing T-cell-mediated cytotoxicity. It is approved for the treatment of extensive-stage small cell lung cancer after prior platinum-based chemotherapy, and is under investigation for bladder cancer and melanoma. DLL3 is highly expressed in small cell lung cancer and other neuroendocrine tumors, making it a highly selective therapeutic target.

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

Yes, Tarlatamab is an approved drug. It has reached clinical phase 4. It is classified as a Antibody.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

  • ChEMBL — European Bioinformatics Institute (EBI). CHEMBL5095292. Open-access bioactivity database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.

إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.