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Tetrazepam

CHEMBL2105527 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
288.8 g/mol
LogP
3.2
Phase
4

Tetrazepam is a benzodiazepine with muscle relaxant, anxiolytic, and anticonvulsant properties that acts by potentiating GABA-A receptor-mediated chloride ion influx, enhancing inhibitory neurotransmission in the central nervous system. It was used as a muscle relaxant for treatment of painful skeletal muscle spasms and was withdrawn from several markets due to serious cutaneous adverse reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis. Its muscle relaxant activity was considered clinically useful but the severe dermatological risks outweighed benefits.

الوزن الجزيئي

288,7700 g/mol

LogP

3,20

TPSA

32,70 Ų

قاعدة ليبينسكي للخمسة

ناجح

آلية العمل

Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.

البنية ثنائية الأبعاد

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SMILES

                    
CN1C(=O)CN=C(C2=CCCCC2)c2cc(Cl)ccc21

                

                

                
                

                    
InChI

                    
InChI=1S/C16H17ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h5,7-9H,2-4,6,10H2,1H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H17ClN2O

                    

                    
                    

                        
HBD / HBA

                        
- / 2

                    

                    
                    

                        
الروابط القابلة للدوران

                        
1

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
20

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
Tetrazepam is a benzodiazepine with muscle relaxant, anxiolytic, and anticonvulsant properties that acts by potentiating GABA-A receptor-mediated chloride ion influx, enhancing inhibitory neurotransmission in the central nervous system. It was used as a muscle relaxant for treatment of painful skeletal muscle spasms and was withdrawn from several markets due to serious cutaneous adverse reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis. Its muscle relaxant activity was considered clinically useful but the severe dermatological risks outweighed benefits.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Tetrazepam is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2105527.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 25215.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.