💊 الأدوية من أ إلى ي 🧬 الأهداف 🛠 الأدوات 📚 الأدلة
جميع الأدوية تصنيفات الأدوية المجالات العلاجية الآثار الجانبية
الأدلة المسرد الجدول الزمني
المقارنات مسارات الأدوية عائلات الأدوية
🇺🇸 English 🇰🇷 한국어 🇯🇵 日本語 🇨🇳 中文简体 🇪🇸 Español 🇧🇷 Português 🇮🇳 हिन्दी 🇸🇦 العربية 🇫🇷 Français 🇷🇺 Русский 🇩🇪 Deutsch 🇹🇷 Türkçe 🇻🇳 Tiếng Việt 🇮🇩 Bahasa Indonesia 🇹🇭 ไทย

Tretinoin

CHEMBL38 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
300.4 g/mol
LogP
6.3
Phase
4

This vitamin A derivative is used topically to treat acne and reduce the appearance of fine wrinkles and sun-damaged skin, and in its oral form (all-trans retinoic acid) it is a key treatment for a specific type of leukemia called acute promyelocytic leukemia (APL). Topically, it works by increasing the rate of skin cell turnover; as a cancer therapy, it triggers abnormal leukemia cells to mature and die. Oral tretinoin must never be used during pregnancy due to the extremely high risk of severe birth defects.

الوزن الجزيئي

300,4000 g/mol

LogP

6,30

TPSA

37,30 Ų

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Pancreatic Cancer Bladder Cancer Non-Small Cell Lung Cancer Rheumatoid Arthritis Asthma Chronic Obstructive Pulmonary Disease Alzheimer's Disease Migraine Schizophrenia Generalized Anxiety Disorder Melanoma Psoriasis Systemic Lupus Erythematosus Multiple Sclerosis Obesity Lymphoma Breast Cancer Atopic Dermatitis Tuberculosis Prostate Cancer Colorectal Cancer Leukemia

آلية العمل

Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1

                

                

                
                

                    
InChI

                    
InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+

                

                

                

                    
                    

                        
Molecular Formula

                        
C20H28O2

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
الروابط القابلة للدوران

                        
5

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
This vitamin A derivative is used topically to treat acne and reduce the appearance of fine wrinkles and sun-damaged skin, and in its oral form (all-trans retinoic acid) it is a key treatment for a specific type of leukemia called acute promyelocytic leukemia (APL). Topically, it works by increasing the rate of skin cell turnover; as a cancer therapy, it triggers abnormal leukemia cells to mature and die. Oral tretinoin must never be used during pregnancy due to the extremely …

                        

                    

                    

                    

                    
                    

                        
                        

                            
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Tretinoin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL38.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 444795.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.