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Tribromsalan

CHEMBL24944 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
449.9 g/mol
LogP
5.0
Phase
4

Tribromsalan (TBS, 3,4,5-tribromosalicylanilide) is a halogenated salicylanilide with antibacterial and antifungal properties that disrupts microbial membrane integrity and inhibits enzyme systems through electrophilic reactivity. It was used as an antimicrobial ingredient in soaps and personal care products but was banned in the United States by the FDA due to photocontact sensitization causing photoallergic contact dermatitis and lack of proven clinical benefit over plain soap. It represents an early antimicrobial triclosan-related agent with unacceptable safety profile.

الوزن الجزيئي

449,9200 g/mol

LogP

5,00

TPSA

49,30 Ų

قاعدة ليبينسكي للخمسة

ناجح

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=C(Nc1ccc(Br)cc1)c1cc(Br)cc(Br)c1O

                

                

                
                

                    
InChI

                    
InChI=1S/C13H8Br3NO2/c14-7-1-3-9(4-2-7)17-13(19)10-5-8(15)6-11(16)12(10)18/h1-6,18H,(H,17,19)

                

                

                

                    
                    

                        
Molecular Formula

                        
C13H8Br3NO2

                    

                    
                    

                        
HBD / HBA

                        
2 / 2

                    

                    
                    

                        
الروابط القابلة للدوران

                        
2

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
19

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
Tribromsalan (TBS, 3,4,5-tribromosalicylanilide) is a halogenated salicylanilide with antibacterial and antifungal properties that disrupts microbial membrane integrity and inhibits enzyme systems through electrophilic reactivity. It was used as an antimicrobial ingredient in soaps and personal care products but was banned in the United States by the FDA due to photocontact sensitization causing photoallergic contact dermatitis and lack of proven clinical benefit over plain soap. It represents an early antimicrobial triclosan-related agent with unacceptable safety profile.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Tribromsalan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL24944.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 14868.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.