Triclosan
Triclosan is a chlorinated aromatic compound with broad-spectrum antimicrobial activity that inhibits bacterial enoyl-acyl carrier protein reductase (ENR, FabI), a key enzyme in bacterial fatty acid synthesis required for cell membrane integrity and growth. It is widely used in consumer products (toothpastes, surgical scrubs, antimicrobial soaps) and has been investigated for treatment of infectious diseases and potential antiproliferative effects in cancer cell lines. Regulatory restrictions have been placed on triclosan in rinse-off consumer products due to concerns about endocrine disruption, antimicrobial resistance selection, and lack of proven clinical benefit.
الوزن الجزيئي
289,5000 g/mol
LogP
5,00
TPSA
29,50 Ų
قاعدة ليبينسكي للخمسة
ناجح
المجالات العلاجية
Pharmacokinetics (PK)
Pharmacodynamics (PD)
البنية ثنائية الأبعاد
Cite this structure
Embed this structure
SMILES
Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl
InChI
InChI=1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
Molecular Formula
C12H7Cl3O2
HBD / HBA
1 / 2
الروابط القابلة للدوران
2
الذرات الثقيلة
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
الأسئلة الشائعة
Triclosan is a chlorinated aromatic compound with broad-spectrum antimicrobial activity that inhibits bacterial enoyl-acyl carrier protein reductase (ENR, FabI), a key enzyme in bacterial fatty acid synthesis required for cell membrane integrity and growth. It is widely used in consumer products (toothpastes, surgical scrubs, antimicrobial soaps) and has been investigated for treatment of infectious diseases and potential antiproliferative effects in cancer cell lines. Regulatory restrictions have been placed on triclosan in rinse-off consumer products due to concerns about endocrine disruption, …
Yes, Triclosan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL849. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5564. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="triclosan"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/triclosan/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/triclosan/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/triclosan/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="triclosan"></drugfyi-drug>