Triflupromazine
Triflupromazine is a trifluoromethyl-substituted phenothiazine typical antipsychotic that blocks dopamine D2 receptors along with significant anti-alpha-adrenergic, antihistaminergic, and anticholinergic activity, used for the management of psychotic disorders and as an antiemetic. It is one of the lower-potency phenothiazines with marked sedative properties. Its pharmacological profile is typical of phenothiazine antipsychotics with the associated risks of extrapyramidal effects and tardive dyskinesia with long-term use.
الوزن الجزيئي
352,4000 g/mol
LogP
5,20
TPSA
31,80 Ų
قاعدة ليبينسكي للخمسة
ناجح
Pharmacokinetics (PK)
Pharmacodynamics (PD)
البنية ثنائية الأبعاد
Cite this structure
Embed this structure
SMILES
CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21
InChI
InChI=1S/C18H19F3N2S/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3
Molecular Formula
C18H19F3N2S
HBD / HBA
- / 6
الروابط القابلة للدوران
4
الذرات الثقيلة
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
الأسئلة الشائعة
Triflupromazine is a trifluoromethyl-substituted phenothiazine typical antipsychotic that blocks dopamine D2 receptors along with significant anti-alpha-adrenergic, antihistaminergic, and anticholinergic activity, used for the management of psychotic disorders and as an antiemetic. It is one of the lower-potency phenothiazines with marked sedative properties. Its pharmacological profile is typical of phenothiazine antipsychotics with the associated risks of extrapyramidal effects and tardive dyskinesia with long-term use.
Yes, Triflupromazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL570. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5568. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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