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Unoprostone Isopropyl

CHEMBL1200661 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
424.6 g/mol
LogP
4.9
Phase
4

Unoprostone isopropyl is a docosanoid analog (derived from a urinary metabolite of prostaglandin) that reduces intraocular pressure by increasing aqueous humor outflow through uveoscleral and trabecular meshwork pathways. It is used in the management of open-angle glaucoma and ocular hypertension as a topical ophthalmic agent. Its prostaglandin-related mechanism complements other classes of glaucoma medications.

الوزن الجزيئي

424,6000 g/mol

LogP

4,90

TPSA

83,80 Ų

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Glaucoma Age-Related Macular Degeneration

آلية العمل

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCCCCCCC(=O)CC[C@@H]1[C@@H](C/C=C\CCCC(=O)OC(C)C)[C@@H](O)C[C@H]1O

                

                

                
                

                    
InChI

                    
InChI=1S/C25H44O5/c1-4-5-6-7-10-13-20(26)16-17-22-21(23(27)18-24(22)28)14-11-8-9-12-15-25(29)30-19(2)3/h8,11,19,21-24,27-28H,4-7,9-10,12-18H2,1-3H3/b11-8-/t21-,22-,23+,24-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C25H44O5

                    

                    
                    

                        
HBD / HBA

                        
2 / 5

                    

                    
                    

                        
الروابط القابلة للدوران

                        
17

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
30

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
Unoprostone isopropyl is a docosanoid analog (derived from a urinary metabolite of prostaglandin) that reduces intraocular pressure by increasing aqueous humor outflow through uveoscleral and trabecular meshwork pathways. It is used in the management of open-angle glaucoma and ocular hypertension as a topical ophthalmic agent. Its prostaglandin-related mechanism complements other classes of glaucoma medications.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Unoprostone Isopropyl is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200661.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5282175.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.