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Ustekinumab

CHEMBL1201835 Phase 4 معتمد Antibody
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
— g/mol
LogP
—
Phase
4

Ustekinumab is a human monoclonal antibody that binds to the p40 subunit shared by interleukin-12 (IL-12) and interleukin-23 (IL-23), blocking their interaction with the IL-12Rβ1 receptor and inhibiting downstream Th1 and Th17 inflammatory pathways. It is approved for the treatment of moderate-to-severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. Its dual IL-12/23 blockade reduces inflammatory cytokine cascades central to immune-mediated diseases.

المجالات العلاجية

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Rheumatoid Arthritis Inflammatory Bowel Disease Psoriasis Systemic Lupus Erythematosus Multiple Sclerosis Type 2 Diabetes Breast Cancer Atopic Dermatitis Cardiovascular Disease Prostate Cancer Colorectal Cancer

آلية العمل

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

HBD / HBA

- / -

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

الأسئلة الشائعة

Ustekinumab is a human monoclonal antibody that binds to the p40 subunit shared by interleukin-12 (IL-12) and interleukin-23 (IL-23), blocking their interaction with the IL-12Rβ1 receptor and inhibiting downstream Th1 and Th17 inflammatory pathways. It is approved for the treatment of moderate-to-severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. Its dual IL-12/23 blockade reduces inflammatory cytokine cascades central to immune-mediated diseases.

As a monoclonal antibody, it binds with high specificity to its target antigen, modulating the immune response through mechanisms including receptor blockade, immune cell engagement, or targeted cytotoxicity.

Yes, Ustekinumab is an approved drug. It has reached clinical phase 4. It is classified as a Antibody.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

  • ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201835. Open-access bioactivity database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.

إخلاء المسؤولية الطبية

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.