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Valproate Sodium

CHEMBL433 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
166.2 g/mol
LogP
—
Phase
4

Valproate sodium (sodium valproate) is the sodium salt of valproic acid, a broad-spectrum antiepileptic agent that enhances GABA-ergic neurotransmission, inhibits voltage-gated sodium channels, and blocks T-type calcium channels to stabilize neuronal membranes and reduce seizure activity. It is used for epilepsy (multiple seizure types), bipolar disorder (mood stabilization), and migraine prophylaxis. Its histone deacetylase inhibitor activity has led to investigation as an epigenetic modifier in cancer.

الوزن الجزيئي

166,1900 g/mol

TPSA

40,10 Ų

المجالات العلاجية

Melanoma Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Glaucoma Non-Small Cell Lung Cancer Asthma Epilepsy Migraine Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Stroke Deep Vein Thrombosis / Pulmonary Embolism Lymphoma Hypertension Major Depressive Disorder Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

آلية العمل

Enhances GABA transmission and blocks sodium/calcium channels.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

Enhances GABA transmission and blocks sodium/calcium channels.

البنية ثنائية الأبعاد

SVG PNG

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SMILES

                    
CCCC(CCC)C(=O)[O-].[Na+]

                

                

                
                

                    
InChI

                    
InChI=1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1

                

                

                

                    
                    

                        
Molecular Formula

                        
C8H15NaO2

                    

                    
                    

                        
HBD / HBA

                        
- / 2

                    

                    
                    

                        
الروابط القابلة للدوران

                        
5

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
11

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
Valproate sodium (sodium valproate) is the sodium salt of valproic acid, a broad-spectrum antiepileptic agent that enhances GABA-ergic neurotransmission, inhibits voltage-gated sodium channels, and blocks T-type calcium channels to stabilize neuronal membranes and reduce seizure activity. It is used for epilepsy (multiple seizure types), bipolar disorder (mood stabilization), and migraine prophylaxis. Its histone deacetylase inhibitor activity has led to investigation as an epigenetic modifier in cancer.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Enhances GABA transmission and blocks sodium/calcium channels.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Valproate Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL433.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 16760703.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.