Velaglucerase Alfa
Velaglucerase alfa is a recombinant human lysosomal enzyme (glucocerebrosidase) produced in plant cell culture that catalyzes the hydrolysis of glucocerebroside to glucose and ceramide, replacing the deficient enzyme in patients with type 1 Gaucher disease. Administered by intravenous infusion, it is taken up by macrophages via mannose receptors and reduces the pathological accumulation of glucocerebroside in the liver, spleen, and bone marrow. Its plant cell expression system results in mannose-terminated N-glycans that enhance uptake efficiency.
آلية العمل
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
HBD / HBA
- / -
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
الأسئلة الشائعة
Velaglucerase alfa is a recombinant human lysosomal enzyme (glucocerebrosidase) produced in plant cell culture that catalyzes the hydrolysis of glucocerebroside to glucose and ceramide, replacing the deficient enzyme in patients with type 1 Gaucher disease. Administered by intravenous infusion, it is taken up by macrophages via mannose receptors and reduces the pathological accumulation of glucocerebroside in the liver, spleen, and bone marrow. Its plant cell expression system results in mannose-terminated N-glycans that enhance uptake efficiency.
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
Yes, Velaglucerase Alfa is an approved drug. It has reached clinical phase 4. It is classified as a Enzyme.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201865. Open-access bioactivity database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.
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