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Vibegron

CHEMBL2107826 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
444.5 g/mol
LogP
1.8
Phase
4

Vibegron is a selective beta-3 adrenergic receptor agonist that activates β3 receptors in bladder smooth muscle (detrusor), causing relaxation and increasing bladder capacity while reducing urinary urgency and frequency without affecting bladder contractility during voiding. It is approved for overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency in adults. As a β3 agonist, it offers an alternative mechanism to antimuscarinics with potentially fewer systemic anticholinergic side effects.

الوزن الجزيئي

444,5000 g/mol

LogP

1,80

TPSA

94,00 Ų

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Obesity

آلية العمل

Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
O=C(Nc1ccc(C[C@@H]2CC[C@H]([C@H](O)c3ccccc3)N2)cc1)[C@@H]1CCc2nccc(=O)n21

                

                

                
                

                    
InChI

                    
InChI=1S/C26H28N4O3/c31-24-14-15-27-23-13-12-22(30(23)24)26(33)29-19-8-6-17(7-9-19)16-20-10-11-21(28-20)25(32)18-4-2-1-3-5-18/h1-9,14-15,20-22,25,28,32H,10-13,16H2,(H,29,33)/t20-,21+,22-,25+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C26H28N4O3

                    

                    
                    

                        
HBD / HBA

                        
3 / 5

                    

                    
                    

                        
الروابط القابلة للدوران

                        
6

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
33

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
Vibegron is a selective beta-3 adrenergic receptor agonist that activates β3 receptors in bladder smooth muscle (detrusor), causing relaxation and increasing bladder capacity while reducing urinary urgency and frequency without affecting bladder contractility during voiding. It is approved for overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency in adults. As a β3 agonist, it offers an alternative mechanism to antimuscarinics with potentially fewer systemic anticholinergic side effects.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Vibegron is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2107826.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 44472635.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.