Major
Probable
الوصف
Diazepam and quetiapine together significantly increase CNS depression and carry risk of severe sedation and cardiorespiratory compromise.
الآلية
Additive CNS depression through complementary receptor mechanisms (GABA-A vs. H1/alpha-1/D2 blockade); quetiapine also prolongs QT, adding cardiac risk.
الأهمية السريرية
Excess sedation and cardiovascular events are documented with the combination; particularly risky in elderly or medically ill patients.
التدبير
Use at minimum doses only when clearly indicated; monitor sedation level, ECG, and vital signs.