Major
Established
الوصف
Pregabalin potentiates the respiratory depressant and sedative effects of morphine, creating a high-risk combination for overdose.
الآلية
Pregabalin binds alpha-2-delta calcium channel subunits, reducing excitatory neurotransmission; additive CNS depression occurs with opioid receptor activation.
الأهمية السريرية
Post-marketing surveillance data show increased opioid-related overdose mortality when pregabalin is co-prescribed.
التدبير
Use only when benefits outweigh risks; prescribe the lowest effective doses and instruct patients about respiratory depression warning signs.