Afatinib vs Osimertinib

## Afatinib vs Osimertinib: Overview

This comparison examines the pharmacological differences between **Afatinib** and **Osimertinib**.

## Mechanism of Action

**Afatinib**: Irreversible covalent inhibitor of ErbB family (EGFR/HER1, HER2, HER4) tyrosine kinases.

**Osimertinib**: Third-generation irreversible EGFR TKI targeting T790M resistance mutation and activating mutations.

## Pharmacokinetics

**Half-life**: Afatinib — 37 hours; Osimertinib — 48 hours.

## Chemical Properties

**Molecular Formula**: Afatinib — C24H25ClFN5O3; Osimertinib — C28H33N7O2.

**Molecular Weight**: Afatinib — 485.9400 g/mol; Osimertinib — 499.6050 g/mol.

**Type**: Afatinib — Small molecule; Osimertinib — Small molecule.