Atezolizumab vs Methotrexate

## Atezolizumab vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Atezolizumab** and **Methotrexate**.

## Mechanism of Action

**Atezolizumab**: Fully human anti-PD-L1 IgG1 monoclonal antibody blocking PD-L1 interaction with PD-1 and B7.1.

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Atezolizumab — 27 days; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Atezolizumab — N/A; Methotrexate — C20H22N8O5.

**Molecular Weight**: Atezolizumab — N/A; Methotrexate — 454.4400 g/mol.

**Type**: Atezolizumab — Antibody; Methotrexate — Small molecule.