Atezolizumab vs Tofacitinib

## Atezolizumab vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Atezolizumab** and **Tofacitinib**.

## Mechanism of Action

**Atezolizumab**: Fully human anti-PD-L1 IgG1 monoclonal antibody blocking PD-L1 interaction with PD-1 and B7.1.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Atezolizumab — 27 days; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Atezolizumab — N/A; Tofacitinib — C16H20N6O.

**Molecular Weight**: Atezolizumab — N/A; Tofacitinib — 312.3700 g/mol.

**Type**: Atezolizumab — Antibody; Tofacitinib — Small molecule.