Buprenorphine vs Fentanyl

Buprenorphine vs Fentanyl: Overview

This comparison examines the pharmacological differences between Buprenorphine and Fentanyl.

Mechanism of Action

Buprenorphine: Partial mu-opioid receptor agonist and kappa antagonist with high receptor affinity.

Fentanyl: Highly potent synthetic mu-opioid receptor agonist approximately 100 times more potent than morphine.

Pharmacokinetics

Half-life: Buprenorphine — 24-42 hours; Fentanyl — 2-4 hours.

Chemical Properties

Molecular Formula: Buprenorphine — C29H41NO4; Fentanyl — C22H28N2O.

Molecular Weight: Buprenorphine — 467.6430 g/mol; Fentanyl — 336.4700 g/mol.

Type: Buprenorphine — Small molecule; Fentanyl — Small molecule.