Buprenorphine vs Morphine

Buprenorphine vs Morphine: Overview

This comparison examines the pharmacological differences between Buprenorphine and Morphine.

Mechanism of Action

Buprenorphine: Partial mu-opioid receptor agonist and kappa antagonist with high receptor affinity.

Morphine: Mu-opioid receptor agonist.

Pharmacokinetics

Half-life: Buprenorphine — 24-42 hours; Morphine — 2-3 hours.

Chemical Properties

Molecular Formula: Buprenorphine — C29H41NO4; Morphine — C17H19NO3.

Molecular Weight: Buprenorphine — 467.6430 g/mol; Morphine — 285.3380 g/mol.

Type: Buprenorphine — Small molecule; Morphine — Small molecule.