Bupropion vs Sertraline

Bupropion vs Sertraline: Overview

This comparison examines the pharmacological differences between Bupropion and Sertraline.

Mechanism of Action

Bupropion: Norepinephrine-dopamine reuptake inhibitor (NDRI).

Sertraline: Selective serotonin reuptake inhibitor (SSRI).

Pharmacokinetics

Half-life: Bupropion — 21 hours; Sertraline — 26 hours.

Chemical Properties

Molecular Formula: Bupropion — C13H18ClNO; Sertraline — C17H17Cl2N.

Molecular Weight: Bupropion — 239.7420 g/mol; Sertraline — 306.2290 g/mol.

Type: Bupropion — Small molecule; Sertraline — Small molecule.