Canagliflozin vs Dapagliflozin

Canagliflozin vs Dapagliflozin: Overview

This comparison examines the pharmacological differences between Canagliflozin and Dapagliflozin.

Mechanism of Action

Canagliflozin: Selective SGLT2 inhibitor reducing renal glucose reabsorption and lowering blood glucose.

Dapagliflozin: Selective SGLT2 inhibitor reducing renal glucose and sodium reabsorption.

Pharmacokinetics

Half-life: Canagliflozin — 10.6 hours; Dapagliflozin — 12.9 hours.

Chemical Properties

Molecular Formula: Canagliflozin — C24H25FO5S; Dapagliflozin — C21H25ClO6.

Molecular Weight: Canagliflozin — 444.5170 g/mol; Dapagliflozin — 408.8730 g/mol.

Type: Canagliflozin — Small molecule; Dapagliflozin — Small molecule.