Canagliflozin vs Sitagliptin

Canagliflozin vs Sitagliptin: Overview

This comparison examines the pharmacological differences between Canagliflozin and Sitagliptin.

Mechanism of Action

Canagliflozin: Selective SGLT2 inhibitor reducing renal glucose reabsorption and lowering blood glucose.

Sitagliptin: DPP-4 inhibitor increasing incretin levels.

Pharmacokinetics

Half-life: Canagliflozin — 10.6 hours; Sitagliptin — 12.4 hours.

Chemical Properties

Molecular Formula: Canagliflozin — C24H25FO5S; Sitagliptin — C16H15F6N5O.

Molecular Weight: Canagliflozin — 444.5170 g/mol; Sitagliptin — 407.3140 g/mol.

Type: Canagliflozin — Small molecule; Sitagliptin — Small molecule.