Captopril vs Digoxin

Captopril vs Digoxin: Overview

This comparison examines the pharmacological differences between Captopril and Digoxin.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Digoxin: Inhibits Na+/K+-ATPase, increasing intracellular calcium.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Digoxin — 36-48 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Digoxin — C41H64O14.

Molecular Weight: Captopril — 217.2850 g/mol; Digoxin — 780.9430 g/mol.

Type: Captopril — Small molecule; Digoxin — Small molecule.