Captopril vs Furosemide

Captopril vs Furosemide: Overview

This comparison examines the pharmacological differences between Captopril and Furosemide.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Furosemide: Loop diuretic inhibiting Na-K-2Cl cotransporter.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Furosemide — 2 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Furosemide — C12H11ClN2O5S.

Molecular Weight: Captopril — 217.2850 g/mol; Furosemide — 330.7440 g/mol.

Type: Captopril — Small molecule; Furosemide — Small molecule.