Captopril vs Metformin

Captopril vs Metformin: Overview

This comparison examines the pharmacological differences between Captopril and Metformin.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Metformin: Activates AMP-activated protein kinase, decreasing hepatic glucose production.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Metformin — 4-9 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Metformin — C4H11N5.

Molecular Weight: Captopril — 217.2850 g/mol; Metformin — 129.1640 g/mol.

Type: Captopril — Small molecule; Metformin — Small molecule.