Captopril vs Methotrexate

Captopril vs Methotrexate: Overview

This comparison examines the pharmacological differences between Captopril and Methotrexate.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Methotrexate: Dihydrofolate reductase inhibitor.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Methotrexate — 3-10 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Methotrexate — C20H22N8O5.

Molecular Weight: Captopril — 217.2850 g/mol; Methotrexate — 454.4400 g/mol.

Type: Captopril — Small molecule; Methotrexate — Small molecule.