Captopril vs Nitroglycerin

Captopril vs Nitroglycerin: Overview

This comparison examines the pharmacological differences between Captopril and Nitroglycerin.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Nitroglycerin: Nitric oxide donor causing venous and arterial vasodilation.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Nitroglycerin — 1-4 minutes.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Nitroglycerin — C3H5N3O9.

Molecular Weight: Captopril — 217.2850 g/mol; Nitroglycerin — 227.0870 g/mol.

Type: Captopril — Small molecule; Nitroglycerin — Small molecule.