Captopril vs Telmisartan

Captopril vs Telmisartan: Overview

This comparison examines the pharmacological differences between Captopril and Telmisartan.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Telmisartan: Selective angiotensin II type 1 receptor antagonist; also a partial PPAR-gamma agonist.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Telmisartan — 24 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Telmisartan — C33H30N4O2.

Molecular Weight: Captopril — 217.2850 g/mol; Telmisartan — 514.6230 g/mol.

Type: Captopril — Small molecule; Telmisartan — Small molecule.