Captopril vs Telmisartan

## Captopril vs Telmisartan: Overview

This comparison examines the pharmacological differences between **Captopril** and **Telmisartan**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Telmisartan**: Selective angiotensin II type 1 receptor antagonist; also a partial PPAR-gamma agonist.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Telmisartan — 24 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Telmisartan — C33H30N4O2.

**Molecular Weight**: Captopril — 217.2850 g/mol; Telmisartan — 514.6230 g/mol.

**Type**: Captopril — Small molecule; Telmisartan — Small molecule.