Celecoxib vs Methotrexate

## Celecoxib vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Celecoxib** and **Methotrexate**.

## Mechanism of Action

**Celecoxib**: Selective COX-2 inhibitor.

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Celecoxib — 11 hours; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Celecoxib — C17H14F3N3O2S; Methotrexate — C20H22N8O5.

**Molecular Weight**: Celecoxib — 381.3730 g/mol; Methotrexate — 454.4400 g/mol.

**Type**: Celecoxib — Small molecule; Methotrexate — Small molecule.