Cetirizine vs Loratadine

Cetirizine vs Loratadine: Overview

This comparison examines the pharmacological differences between Cetirizine and Loratadine.

Mechanism of Action

Cetirizine: Second-generation H1 antihistamine.

Loratadine: Second-generation H1 antihistamine with minimal CNS effects.

Pharmacokinetics

Half-life: Cetirizine — 6.5-10 hours; Loratadine — 8 hours.

Chemical Properties

Molecular Formula: Cetirizine — C21H25ClN2O3; Loratadine — C22H23ClN2O2.

Molecular Weight: Cetirizine — 388.8900 g/mol; Loratadine — 382.8800 g/mol.

Type: Cetirizine — Small molecule; Loratadine — Small molecule.