Cetirizine vs Loratadine

## Cetirizine vs Loratadine: Overview

This comparison examines the pharmacological differences between **Cetirizine** and **Loratadine**.

## Mechanism of Action

**Cetirizine**: Second-generation H1 antihistamine.

**Loratadine**: Second-generation H1 antihistamine with minimal CNS effects.

## Pharmacokinetics

**Half-life**: Cetirizine — 6.5-10 hours; Loratadine — 8 hours.

## Chemical Properties

**Molecular Formula**: Cetirizine — C21H25ClN2O3; Loratadine — C22H23ClN2O2.

**Molecular Weight**: Cetirizine — 388.8900 g/mol; Loratadine — 382.8800 g/mol.

**Type**: Cetirizine — Small molecule; Loratadine — Small molecule.