Ciprofloxacin vs Trimethoprim

Ciprofloxacin vs Trimethoprim: Overview

This comparison examines the pharmacological differences between Ciprofloxacin and Trimethoprim.

Mechanism of Action

Ciprofloxacin: Inhibits bacterial DNA gyrase and topoisomerase IV.

Trimethoprim: Dihydrofolate reductase inhibitor (bacterial selective).

Pharmacokinetics

Half-life: Ciprofloxacin — 4 hours; Trimethoprim — 8-10 hours.

Chemical Properties

Molecular Formula: Ciprofloxacin — C17H18FN3O3; Trimethoprim — C14H18N4O3.

Molecular Weight: Ciprofloxacin — 331.3460 g/mol; Trimethoprim — 290.3180 g/mol.

Type: Ciprofloxacin — Small molecule; Trimethoprim — Small molecule.