Clonazepam vs Diazepam

Clonazepam vs Diazepam: Overview

This comparison examines the pharmacological differences between Clonazepam and Diazepam.

Mechanism of Action

Clonazepam: Long-acting benzodiazepine positive allosteric modulator of GABA-A receptors.

Diazepam: Positive allosteric modulator of GABA-A receptors.

Pharmacokinetics

Half-life: Clonazepam — 30-40 hours; Diazepam — 20-100 hours.

Chemical Properties

Molecular Formula: Clonazepam — C15H10ClN3O3; Diazepam — C16H13ClN2O.

Molecular Weight: Clonazepam — 315.7150 g/mol; Diazepam — 284.7400 g/mol.

Type: Clonazepam — Small molecule; Diazepam — Small molecule.