Cyclosporine vs Tacrolimus

Cyclosporine vs Tacrolimus: Overview

This comparison examines the pharmacological differences between Cyclosporine and Tacrolimus.

Mechanism of Action

Cyclosporine: Calcineurin inhibitor suppressing T-cell activation.

Tacrolimus: Calcineurin inhibitor binding FKBP12; suppresses IL-2 transcription.

Pharmacokinetics

Half-life: Cyclosporine — 6-12 hours; Tacrolimus — 12 hours.

Chemical Properties

Molecular Formula: Cyclosporine — C62H111N11O12; Tacrolimus — C44H69NO12.

Molecular Weight: Cyclosporine — 1202.6100 g/mol; Tacrolimus — 804.0180 g/mol.

Type: Cyclosporine — Protein; Tacrolimus — Small molecule.