Dapagliflozin vs Hydrochlorothiazide

Dapagliflozin vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between Dapagliflozin and Hydrochlorothiazide.

Mechanism of Action

Dapagliflozin: Selective SGLT2 inhibitor reducing renal glucose and sodium reabsorption.

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Pharmacokinetics

Half-life: Dapagliflozin — 12.9 hours; Hydrochlorothiazide — 6-15 hours.

Chemical Properties

Molecular Formula: Dapagliflozin — C21H25ClO6; Hydrochlorothiazide — C7H8ClN3O4S2.

Molecular Weight: Dapagliflozin — 408.8730 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

Type: Dapagliflozin — Small molecule; Hydrochlorothiazide — Small molecule.