Digoxin vs Sildenafil

Digoxin vs Sildenafil: Overview

This comparison examines the pharmacological differences between Digoxin and Sildenafil.

Mechanism of Action

Digoxin: Inhibits Na+/K+-ATPase, increasing intracellular calcium.

Sildenafil: Selective PDE5 inhibitor increasing cGMP.

Pharmacokinetics

Half-life: Digoxin — 36-48 hours; Sildenafil — 4 hours.

Chemical Properties

Molecular Formula: Digoxin — C41H64O14; Sildenafil — C22H30N6O4S.

Molecular Weight: Digoxin — 780.9430 g/mol; Sildenafil — 474.5800 g/mol.

Type: Digoxin — Small molecule; Sildenafil — Small molecule.