Digoxin vs Sildenafil

## Digoxin vs Sildenafil: Overview

This comparison examines the pharmacological differences between **Digoxin** and **Sildenafil**.

## Mechanism of Action

**Digoxin**: Inhibits Na+/K+-ATPase, increasing intracellular calcium.

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

## Pharmacokinetics

**Half-life**: Digoxin — 36-48 hours; Sildenafil — 4 hours.

## Chemical Properties

**Molecular Formula**: Digoxin — C41H64O14; Sildenafil — C22H30N6O4S.

**Molecular Weight**: Digoxin — 780.9430 g/mol; Sildenafil — 474.5800 g/mol.

**Type**: Digoxin — Small molecule; Sildenafil — Small molecule.