Digoxin vs Spironolactone

Digoxin vs Spironolactone: Overview

This comparison examines the pharmacological differences between Digoxin and Spironolactone.

Mechanism of Action

Digoxin: Inhibits Na+/K+-ATPase, increasing intracellular calcium.

Spironolactone: Mineralocorticoid receptor antagonist.

Pharmacokinetics

Half-life: Digoxin — 36-48 hours; Spironolactone — 1.4 hours.

Chemical Properties

Molecular Formula: Digoxin — C41H64O14; Spironolactone — C24H32O4S.

Molecular Weight: Digoxin — 780.9430 g/mol; Spironolactone — 416.5740 g/mol.

Type: Digoxin — Small molecule; Spironolactone — Small molecule.