Diphenhydramine vs Donepezil

## Diphenhydramine vs Donepezil: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Donepezil**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Donepezil**: Reversible acetylcholinesterase inhibitor.

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Donepezil — 70 hours.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Donepezil — C24H29NO3.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Donepezil — 379.4920 g/mol.

**Type**: Diphenhydramine — Small molecule; Donepezil — Small molecule.