Diphenhydramine vs Durvalumab

## Diphenhydramine vs Durvalumab: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Durvalumab**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Durvalumab**: Human IgG1 kappa anti-PD-L1 monoclonal antibody blocking PD-L1 binding to PD-1 and CD80.

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Durvalumab — 17 days.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Durvalumab — N/A.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Durvalumab — N/A.

**Type**: Diphenhydramine — Small molecule; Durvalumab — Antibody.