Diphenhydramine vs Lorazepam

## Diphenhydramine vs Lorazepam: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Lorazepam**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Lorazepam**: Intermediate-acting benzodiazepine enhancing GABA-A receptor chloride conductance.

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Lorazepam — 10-20 hours.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Lorazepam — C15H10Cl2N2O2.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Lorazepam — 321.1580 g/mol.

**Type**: Diphenhydramine — Small molecule; Lorazepam — Small molecule.