Diphenhydramine vs Lorazepam

Diphenhydramine vs Lorazepam: Overview

This comparison examines the pharmacological differences between Diphenhydramine and Lorazepam.

Mechanism of Action

Diphenhydramine: First-generation H1 antihistamine with anticholinergic properties.

Lorazepam: Intermediate-acting benzodiazepine enhancing GABA-A receptor chloride conductance.

Pharmacokinetics

Half-life: Diphenhydramine — 2-8 hours; Lorazepam — 10-20 hours.

Chemical Properties

Molecular Formula: Diphenhydramine — C17H21NO; Lorazepam — C15H10Cl2N2O2.

Molecular Weight: Diphenhydramine — 255.3550 g/mol; Lorazepam — 321.1580 g/mol.

Type: Diphenhydramine — Small molecule; Lorazepam — Small molecule.